![]() Quetiapine compared to typical antipsychotics for schizophrenia Summary SchizophreniaĪ 2013 Cochrane review compared quetiapine to typical antipsychotics: ![]() Quetiapine targets both positive and secondary negative symptoms of schizophrenia. Quetiapine is primarily used to treat schizophrenia or bipolar disorder. Medical uses Quetiapine (Seroquel) 25 mg tablets, next to US one-cent coin for comparison Seroquel XR 150 mg tablet box It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 64th most commonly prescribed medication in the United States, with more than 10 million prescriptions. Quetiapine was developed in 1985 and approved for medical use in the United States in 1997. Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine. Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth. In older people with dementia, its use increases the risk of death. Other side effects include low blood pressure with standing, seizures, a prolonged erection, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome. Ĭommon side effects include sleepiness, constipation, weight gain, and dry mouth. Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use do not appear to generally outweigh the side effects. Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
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